Recently, there has been increasing interest in the treatment of different types of cancer through medicinal plants. The low cost, easy access and fewer side effects of healing plants compare to synthetic compounds publicize their usage. The aim of this special issue named “The most effective medicinal plants in cancer treatment” is to introduce different plants which are using from ancient till now in cancer therapy.
As different types of cancer show similar pathology, this special issue tries to highlight the most powerful plant-derived compounds effective in the treatment of cancer. The goal of this issue is to collect data reported from different researchers, labs, various countries and diverse studies to make a complete list of the strongest therapeutic plants.
The target of this special issue is to publish all studies about the effectiveness of individual plants and/or their co-administration or comparison with synthetic drugs in treatment of various types of tumors. Hence, all researchers are invited to submit their valuable findings and/or conceptual records in this special issue.
02Meet the Guest Editors
Our distinguished editors bring deep subject-matter expertise to curate high-quality research and ensure a rigorous peer-review process.
Lead Guest Editor
Marjaneh Motaghed
Oncological and Radiological Department, Advanced Medical and Dental Institute, University Sains Malaysia, Penang, Malaysia
Guest Editor
Qutaiba Kafi Jassim
Sorman Medical Engineering College, Al Zaweah University, Zaweah, Libya
Guest Editor
Salem Bashanfer
Faculty of Medicine and Health Sciences, Hodiedah University, Hodiedah, Yemen
03Published Articles
The following articles have been published in this special issue.
Abstract: About 80% of breast cancers are estrogen-receptor positive. The research carried out herein focused on the effect of Thymoquinone which is an active compound of Nigella sativa seed on estrogen-receptor positive breast cancer MCF7 cell line. The percentage of apoptotic cells was found using Annexin V-FITC apoptosis detection kit. CycleTEST PLUS DNA Reagent was used to distinguish distribution of treated cells between different cell cycle phases. DNA microarray identified the regulated genes, level of expressed genes, gene ontology and pathway networks. Significant arrest of treated cells at G1 phase suggested cytostatic effect of Thymoquinone 100 µM after 24 hours at p-value < 0.05 which was similar to anti-estrogenic compounds such as Tamoxifen. Cytotoxic effect of Thymoquinone 100 µM was found through highly significant accumulation of cells at sub-G1 phase after 72 hours at p-value < 0.0001. CYP1A1, CYP1B1, NQO1 and UGT1A8 genes were down regulated after 24 hours treatment with Thymoquinone 50 µM concentration which suggested reduction of catechol estrogens and rising in metoxy forms of estradiol and estrone. Reduction of ER would be predictable due to the down-regulation of CYP1B1 and UGT1A8 genes which reduced affinity of trans-tamoxifen-o-glucuronide to ER. The study proposed the benefits of using Thymoquinone to accelerate Tamoxifen effects in treating breast cancer and reducing its side effects.Abstract: About 80% of breast cancers are estrogen-receptor positive. The research carried out herein focused on the effect of Thymoquinone which is an active compound of Nigella sativa seed on estrogen-receptor positive breast cancer MCF7 cell line. The percentage of apoptotic cells was found using Annexin V-FITC apoptosis detection kit. CycleTEST PLUS DNA ...Show More
Abstract: Adenocarcinoma is known as a common type of cancer which includes 85% of breast carcinoma and 95% of colorectal carcinoma. Up until now, the cytotoxic effect of Thymoquinone on different types of tumor cells has been reported. It was hypothesized that Thymoquinone has similar effect on cancer arising from epithelial cells through gene expression analysis in MCF7 breast cancer and HT-29 colon cancer cell lines. The quantity and quality of RNA samples were identified using RNeasyPlus Mini kit and RNA 6000 Nano LabChip kit, respectively. The purified RNA samples of MCF7 cells were used in two-color 8×60K cDNA array platform with SurePrint Agilent technology. The hybridized cRNA/cDNA probes were identified due to labeling with red and green cyanine dyes using GEX hybridization buffer HI-RPM. LOWESS normalization reduced the dye bias on the array slide using feature extraction software. Gene ontology analysis was done after performing different steps of filtering to reduce not satisfied genes using Gene Spring software. Two-step RT-qPCR assay using Taq Man fast advanced master mix analyzed the most up and down regulated genes in MCF7 compared to HT-29 cancer cell lines. The 10 different cancer cell lines in a form of universal reference RNA was used as standard data set comparison and as a positive control RNA in cDNA array and RT-qPCR assay, respectively. The T-test statistical analysis of independent samples showed that there is no significant difference between two types of cell lines due to Thymoquinone treatment with p-value 0.844. Among the selected genes; CARD16, UGT1A8, SLC7A11, IFIT1, IF16 and IFIT3 were expressed significantly (0.009, 0.0001, 0.037, 0.098, 0.0001 and 0.033, respectively) in breast cancer compare to colon cancer cells. The findings indicated similar effect of Thymoquinone on cancer arising from epithelial cells.Abstract: Adenocarcinoma is known as a common type of cancer which includes 85% of breast carcinoma and 95% of colorectal carcinoma. Up until now, the cytotoxic effect of Thymoquinone on different types of tumor cells has been reported. It was hypothesized that Thymoquinone has similar effect on cancer arising from epithelial cells through gene expression an...Show More
Issue: Volume 3, Issue 2-2, March 2015Pages: 7-14Received: 10 December 2014Accepted: 13 December 2014Published: 27 December 2014Abstract: About 80% of breast cancers are estrogen-receptor positive. The research carried out herein focused on the effect of Thymoquinone which is an active compound of Nigella sativa seed on estrogen-receptor positive breast cancer MCF7 cell line. The percentage of apoptotic cells was found using Annexin V-FITC apoptosis detection kit. CycleTEST PLUS DNA ... Show More