Mitochondria: Implications in Human Health and Diseases
View Published Articles →01About This Special Issue
Mitochondria play a central role in energy metabolism. It is now well established that functional mitochondria are important in the regulation of several essential cellular metabolic pathways, apoptosis, signal transduction and cell growth. It is of particular importance in the high energy requiring tissues such as brain, heart and muscle. Mitochondrial defects have been implicated in a wide range of clinical conditions such as cancer, neuro-degeneration, obesity, diabetes, ageing and age associated disorders including Parkinson's, Alzheimer's and loss of muscle mass. Since mitochondrial DNA is maternally inherited, mutations in the mitochondrial DNA have also been linked to rare childhood diseases and metabolic syndromes. In recent years tremendous progress has been made in deciphering novel mechanisms of mitochondria in cellular signaling. Rerouting of metabolites in mitochondrial TCA cycle provides alternative ways to generate building blocks such as nucleotides and amino acids for cellular growth and proliferation. Damaged mitochondria are removed through autophagy or functional mitochondria are maintained through enhancing mitochondrial biogenesis. Mitochondrial fission and fusion mechanisms are providing new insights into mitochondrial quality control. In this special issue we will highlight functional aspects of mitochondria in maintaining cellular homeostasis and also the consequences of mitochondrial defects that contributes in disease progression.02Meet the Guest Editors
Our distinguished editors bring deep subject-matter expertise to curate high-quality research and ensure a rigorous peer-review process.
Lead Guest Editor
Lokendra Sharma
Center for Biological Sciences, Central University of Bihar, Patna, India
Guest Editor
Rosonald Bell
Pfizer Inc., Groton, United States
Guest Editor
jack sparrow
js, China
Guest Editor
Ashutosh Shrivastava
Division of Experimental Medicine, Beth Israel Deaconess Medical Center, Boston, United States
Guest Editor
Khyati Dave
Department of Biodesign, Stanford University, Palo Alto, United States
Guest Editor
RAKESH PONNALA
DOW AGROSCIENCES LLC, ZIONSVILLE, United States
Guest Editor
Soroosh Solhjoo
Johns Hopkins University, Baltimore, United States
Guest Editor
Cunye Qu
Center for Craniofacial Molecular Biology, University of Southern California, Losangeles, United States
Guest Editor
Şirin Korulu Koç
Department of Molecular Biology and Genetics, Istanbul Arel University, Istanbul, Turkey
Guest Editor
Meenakshi Tiwari
Department of Pathology and Laboratory Medicine, AIIMS-Patna, Patna, India
Guest Editor
Aditya Sen
Department of Biochemistry and Molecular Biology, Uniformed Services University, Bethesda, United States
Guest Editor
Soumyabrata Munshi
Department of Neuroscience, Rosalind Franklin University of Medicine and Science, North Chicago, United States
Guest Editor
Rizwanul Haque
Centre for Biological Sciences (Biotechnology), Central University South Bihar, Patna, India
Guest Editor
Ashok Kumar
Department of Biochemistry, All India Institute of Medical Sciences (AIIMS), Bhopal, India
Guest Editor
Umesh Wankhade
NIH, Bethesda, United States
Guest Editor
Palas Chanda
Department of Cardiovascular Sciences, Houston Methodist Research Institute, houston, United States
Guest Editor
Fnu Gaurav
Department of Surgery, School of Medicine, KU Medical Center, Kansas, United States
Guest Editor
Lei Wang
Johns Hopkins University, School of Medicine, Wilmer Eye Institute, Baltimore, United States
Guest Editor
Saipraveen Srinivasan
Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, United States
Guest Editor
Yanqing zhang
, United States
Guest Editor
Ahmed M.S. Hegazy
Department of Anatomy and Embryology, Benha Faculty of Medicine, Benha University, Benha, Egypt
Guest Editor
Masumeh Saeidi
Department of Medical Education, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
03Published Articles
The following articles have been published in this special issue.
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Mitochondria: A Key Player in Stem Cell Fate
Issue: Volume 3, Issue 2-1, April 2015Pages: 31-37Received: 28 February 2015Accepted: 1 May 2015Published: 9 June 2015Abstract: Mitochondria are highly dynamic organelles that undergo cycles of fusion and fission important for their function, maintenance, and quality control as well as direct or indirect role in different types of stem cells fate decisions. Stem cells have potential for numerous biomedical applications; however the major bottle neck in stem cell field is th... Show More -
Interaction Between Mitochondria and Caspases: Apoptotic and Non-Apoptotic Roles
Issue: Volume 3, Issue 2-1, April 2015Pages: 22-30Received: 27 February 2015Accepted: 9 March 2015Published: 20 March 2015Abstract: Mitochondria, play an important role in a variety of processes including energy production, apoptosis, autophagy and inflammation. Caspases, are proteases that play an essential role in mediating apoptotic process of programmed cell death. An association between mitochondria and caspases is very well defined during apoptosis. Besides apoptosis, eme... Show More -
The Mechanisms of Mitochondria-Mediated Apoptosis in Cancer Chemotherapy
Issue: Volume 3, Issue 2-1, April 2015Pages: 17-21Received: 3 February 2015Accepted: 27 February 2015Published: 12 March 2015Abstract: Cell metabolism and signal transduction has usually been considered independent processes. Interestingly mitochondria is an intracellular organelle that perform energy production to fuel the cell to carry out its normal functions, however, in certain circumstances, its components can also carry out programmed cell destruction via its resident prote... Show More -
Mitochondrial Alteration: A Major Player in Carcinogenesis
Issue: Volume 3, Issue 2-1, April 2015Pages: 8-16Received: 28 January 2015Accepted: 28 January 2015Published: 10 February 2015Abstract: In recent years we have witnessed mounting evidences on how a normal cell changes its cellular signaling and metabolic pathways to become highly proliferative cancer cell. Since mitochondrion is a major hub of energy production and several metabolic pathways, it is taking the center stage in defining alterations in energy homeostasis and metabolic ... Show More -
Regulation of Mitochondrial Function by Bioactive Sphingolipids
Issue: Volume 3, Issue 2-1, April 2015Pages: 1-7Received: 24 November 2014Accepted: 18 December 2014Published: 10 February 2015Abstract: Sphingolipids such as ceramide, sphingosine and sphingosine 1-phosphate [S1P] are key regulators of various cellular functions. Sphingolipids mediates of cell-stress responses and regulate mitochondrial function. Ceramide and its metabolites play an important role in the development and progression of mitochondria related disorders. Ceramide functi... Show More
